Research Article
MMP2 and MMP10 Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population
Table 3
Genotypic model analysis of relationship between SNPs and steroid-induced ONFH.
| | SNP ID | Model | Genotype | Controls | Cases | Without Adjustment | With Adjustment | | OR (95% CI) | p value | OR (95% CI) | p value |
| | rs470154 | Codominant | G/G | 245 (79.5%) | 210 (73.4%) | 1 | 0.067 | 1 | 0.120 | | G/T | 60 (19.5%) | 67 (23.4%) | 1.30 (0.88-1.93) | 1.27 (0.84-1.92) | | T/T | 3 (1%) | 9 (3.1%) | 3.50 (0.94-13.10) | 3.37 (0.83-13.67) | | Dominant | G/G | 245 (79.5%) | 210 (73.4%) | 1 | 0.078 | 1 | 0.130 | | G/T-T/T | 63 (20.4%) | 76 (26.6%) | 1.41 (0.96-2.06) | 1.36 (0.91-2.04) | | Recessive | G/G-G/T | 305 (99%) | 277 (96.8%) | 1 | 0.055 | 1 | 0.083 | | T/T | 3 (1%) | 9 (3.1%) | 3.30 (0.89-12.33) | 3.20 (0.79-12.95) | | Log-additive | - - - | - - - | - - - | 1.44 (1.02-2.02) | 0.035 | 1.40 (0.98-2.00) | 0.066 | | rs2241146 | Codominant | G/G | 188 (61.2%) | 175 (61.2%) | 1 | 0.078 | 1 | 0.058 | | G/A | 107 (34.9%) | 88 (30.8%) | 0.88 (0.62-1.25) | 0.93 (0.65-1.34) | | A/A | 12 (3.9%) | 23 (8%) | 2.06 (0.99-4.26) | 2.36 (1.10-5.07) | | Dominant | G/G | 188 (61.2%) | 175 (61.2%) | 1 | 0.990 | 1 | 0.710 | | G/A-A/A | 119 (38.8%) | 111 (38.8%) | 1.00 (0.72-1.39) | 1.07 (0.75-1.51) | | Recessive | G/G-G/A | 295 (96.1%) | 263 (92%) | 1 | 0.032 | 1 | 0.018 | | A/A | 12 (3.9%) | 23 (8%) | 2.15 (1.05-4.41) | 2.42 (1.14-5.14) | | Log-additive | - - - | - - - | - - - | 1.12 (0.86-1.46) | 0.400 | 1.19 (0.90-1.58) | 0.230 |
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P values were calculated by Wald test by unconditional logistic regression adjusted for age and gender. P < 0.05 indicates statistical significance. |
