Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro

Table 2

Values of inhibitory concentrations () and Combinatory Index of the phenothiazinium combinations. The concentrations of the dyes alone and in combinations were calculated using the Compusyn software. The software was also used for the determination of the CI between the combined compounds.

Combination (compound 1 + 2)	(compound 1/μM)	(compound 2/μM)	(combination compound 1/μM)	(combination compound 2/μM)	CI
BZ + MB	3.315	0.477	2.262	0.291	1.29
BZ + NMB	2.937	0.100	2.091	0.056	1.26
BZ + TBO	3.024	0.380	2.259	0.178	1.40
BZ + DMMB	3.015	0.078	1.943	0.050	1.28
MB + NMB	0.560	0.112	0.247	0.051	0.90
MB + TBO	0.588	0.322	0.250	0.150	0.89
MB + DMMB	0.391	0.095	0.223	0.044	1.05
NMB + TBO	0.122	0.322	0.042	0.126	0.74
NMB + DMMB	0.101	0.071	0.034	0.033	0.80
TBO + DMMB	0.381	0.080	0.063	0.020	0.42