Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease

Table 3

Correlation of subjective symptoms (OSDI total score) with objective signs characterizing dry eye disease (tBUT, Schirmer test, Lissamine green score and LIPCOF grading) in control persons (Control panel), Crohn’s disease patients (CD panel), and ulcerative colitis patients (UC panel). CI: confidence interval; tBUT: tear breakup time; LIPCOF: lid parallel conjunctival folds; OSDI: ocular surface disease index.

Control	OSDI vs. tBUT (s)	OSDI vs. Schirmer test (mm/5 min)	OSDI vs. Lissamine Green score	OSDI vs. LIPCOF
r (Pearson)	-0.3344	-0.3532	0.3658	0.5076
95% CI	-0.5909 to -0.01649	-0.6046 to -0.03784	0.05223 to 0.6137	0.2243 to 0.7118
p value	0.0402	0.0296	0.0239	0.0011
	CD	OSDI vs. tBUT (s)	OSDI vs. Schirmer test (mm/5 min)	OSDI vs. Lissamine Green score	OSDI vs. LIPCOF
r (Pearson)	-0.09736	-0.05682	0.3399	0.1243
95% CI	-0.4127 to 0.2388	-0.3783 to 0.2769	0.01277 to 0.6013	-0.2129 to 0.4351
p value	0.5721	0.742	0.0425	0.4701
	UC	OSDI vs. tBUT (s)	OSDI vs. Schirmer test (mm/5 min)	OSDI vs. Lissamine Green score	OSDI vs. LIPCOF
r (Pearson)	-0.5512	-0.3646	0.6049	0.607
95% CI	-0.7771 to -0.1995	-0.6589 to 0.02654	0.2841 to 0.8039	0.2871 to 0.8051
p value	0.0043	0.0671	0.0011	0.001