Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B
MAO inhibition by natural phenolic compounds. Recombinant human monoamine oxidases A (a) and B (b) (0.01mg/ml) were exposed to kynuramine dihydrobromide (10μM) for 15 minutes in the absence (control; n=6) or presence (n=3) of clorgyline (1μM), selegiline (0.5μM), or 15 μM of resveratrol, resveratrol 3-glucoside, resveratrol 4’-glucoside, pterostilbene, pterostilbene 4’-glucoside, gnetin-C, vanillin, silybin, chrysin, or α-mangostin. Comparisons were made by one-way ANOVA with Dunnett’s posttest; indicates p<0.05. Control rates for MAO-A and MAO-B were 0.357 ± 0.018 and 0.105 ± 0.010 nmol/min/mg protein, respectively.
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