Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats
Table 4
Effect of EASPA on serum haematological parameters in the subacute toxicity study.
Parameters
Unit
Control
1.75 mg/kg
3.5 mg/kg
7 mg/kg
14 mg/kg
WBC
109/L
6.20 ± 1.61
5.60 ± 0.56
6.40 ± 0.53
7.20 ± 0.35
5.50 ± 0.04
RBC
1012/L
6.12 ± 0.32
6.89 ± 0.08
6.24 ± 0.21
6.66 ± 0.10
6.20 ± 0.13
Haemoglobin
g/dL
11.70 ± 0.37
12.80 ± 0.68
12.90 ± 0.49
13.40 ± 0.17
13.00 ± 0.08
Haematocrit
%
33.10 ± 1.46
37.00 ± 0.47
34.90 ± 1.47
35.90 ± 0.40
34.60 ± 0.71
MCV
fL
109.43 ± 0.78
107.45 ± 0.49
111.70 ± 0.93
107.80 ± 0.44
111.60 ± 0.17
MCH
pg
19.55 ± 0.86
20.10 ± 0.14
20.30 ± 0.28
20.20 ± 0.08
21.00 ± 0.62∗
MCHC
g/dL
35.8 ± 1.25
37.42 ± 0.53
36.95 ± 0.31
37.3 ± 0.17
37.65 ± 1.02∗
PLT
109/L
558.07 ± 109.03
495.33 ±74.24
522.00 ± 10.7
431.00 ± 69.3
535.00 ± 17.4
Lymphocytes
109/L
5.5 ± 0.20
5.87 ± 0.21
5.90 ± 0.49
5.70 ± 0.45
5.1.00 ± 0.04
Monocytes
109/L
0.37 ± 0.06
0.40 ± 0.05
0.30 ± 0.04
0.30 ± 0.04
0.20 ± 0.00
Granules
109/L
0.20 ± 0.00
0.26 ± 0.02
0.20 ± 0.00
0.20 ± 0.00
0.20 ± 0.00
RDW-CV
%
23.90 ± 0.54
23.75 ± 0.19
23.40 ± 0.26
23.70 ± 0.31
23.30 ± 0.13
MPV
fL
10.60 ± 0.12
10.40 ± 0.20
10.00 ± 0.26
10.00 ± 0.08
10.10 ± 0.13
PCT
%
0.30 ± 0.05
0.25 ± 0.03
0.26 ± 0.01
0.21 ± 0.03
0.26 ± 0.00
Values are expressed as a mean ± SEM (,, and ∗ = significant difference from the control group).RBC: Total red blood cell count; WBC: total white blood cell count; PLT: platelet count; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RDW-CV: red blood cell distribution width; MPV: mean platelet volume; PCT: procalcitonin.
