PEGylated Polyethylenimine Derivative-Mediated Local Delivery of the shSmad3 Inhibits Intimal Thickening after Vascular Injury
Effects of shSmad3 gene delivery on intimal thickening and VSMCs proliferation after vascular injury. (a) Representative EVG sections of injured arteries 14 days after balloon angioplasty. The distance between arrows indicated the media area. Original magnifications: 200 ×. (b) Representative immunohistochemistry staining of α-SMA 14 days after balloon angioplasty. The distance between the arrows indicated the media area. Original magnifications: 200 ×. (c) Representative immunohistochemistry staining of PCNA 14 days after balloon angioplasty. The arrow indicated the internal elastic lamina. Original magnifications: 200 ×. (d) Average intima area for the four injured groups. n = 3. (e) Average I/M area ratios for the four injured groups. n = 3. (f) The ratio of PCNA-positive nuclei to total cell nucleus in intima area. n = 3. Each bar shows as mean ± SD. P < 0.05, P < 0.01; P < 0.001. a, PEG-Et 1:1/shSmad3 polyplex treated group; b, PEG-Et 1:1 treated group; c, PBS treated group; d, untreated group.
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