BioMed Research International / 2019 / Article / Fig 8

Research Article

PEGylated Polyethylenimine Derivative-Mediated Local Delivery of the shSmad3 Inhibits Intimal Thickening after Vascular Injury

Figure 8

Effect of Smad3 gene delivery on intimal collagen content after vascular injury. (a) Representative Masson staining sections of injured arteries 14 days after balloon angioplasty. The distance between the arrows indicated the media area. Original magnifications: 200 ×. (b) The ratio of collagen content to total intimal area in the four injured groups. (c) qRT-PCR analysis of Col I and Col III mRNA expression, GAPDH served as internal standard. n = 3. (d) Western blot analysis of Col I and Col III protein expression, GAPDH served as internal standard. Each bar shows as mean ± SD. P < 0.01; P < 0.001. a, PEG-Et 1:1/shSmad3 polyplex treated group; b, PEG-Et 1:1 treated group; c, PBS treated group; d, untreated group.


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