Review Article

Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the studies included in the review.

Author  
year
CountryStudy designNo. of patients  
(n)
Gender  
(M/F)
AgeDurationProgram of PRCG groupOutcomes

Vainshelboim et al. 2016[16]IsraelRCTs,  
2arms
32  
PR 15  
CG 17
PR 10/5  
CG 11/6
PR 68.8±6  
CG 66±9
12-weekAerobic, Resistance,   
Flexibility exercise,   
Modes and deep breathing exercises
Regular  
care
FVC%%, DLCO%%, 6MWD, IPAQ  
SGRQ scores

Vainshelboim et al. 2015[17]IsraelRCTs,   
2arms
28  
PR 14  
CG 14
/PR 68.8±6  
CG 66±9
11-month follow-upAerobic, Resistance,   
Flexibility exercise,  
Modes and deep breathing exercises
Regular   
care
FVC%%, DLCO%%, 6MWD,   
SGRQ scores, IPAQ
He   
et al. 2016[18]
ChinaRCTs,   
2arms
30  
PR 15  
CG 15
PR 9/6  
CG 8/7
PR 64.87±7.36  
CG 65.33±7.74
12-weekCycle ergometerRegular  
care
FVC%%, DLCO%%, 6MWD, TLC%,  
ATAQ-IPF scores
Gaunaurd  
et al.2014[19]
AmericaRCTs,   
2arms
21  
PR 11  
CG 10
/PR 71±6  
CG 66±7
12 weeks 3-month follow-upEducational lectures, Supervised aerobic,   
Strengthening exercises.
Regular  
care
IPF-specific SGRQ scores  
IPAQ, FVC%, DLCO%%
Robert   
et al. 2014[20]
AmericaRCTs,   
2arms
21  
PR 11  
CG 10
/PR 71±6  
CG 66±7
12 weeksEducational lectures,   
Treadmill walking,   
Semi recumbent cycling, Self-administered,   
Flexibility exercises,   
Strength training
Regular  
care
6MWD,   
TLC%
Nishiyama   
et al. 2008[21]
JapanRCTs,   
2arms
28,   
PR 13  
CG 15
PR 12/1  
CG 9/6
PR 68.1±8.9  
CG 64.5±9.1
10 weeksTreadmill,   
Cycle ergometer test, Supplemental oxygen, Elastic bands, Arm raising, Knee extensions, Educational lectures
Regular  
care
6MWD, SGRQ scores  
FVC%, FEV1, TLC,   
BDI
Dariusz   
et al. 2008[22]
PolandRCTs,   
2arms
30  
PR 16  
CG 14
PR 10/6  
CG 9/5
PR 56.5 ± 6.5  
CG 56.2 ± 7.2
12 weeksInspiratory muscle trainingRegular  
care
6MWD, BDI, SF-36

Abbreviations: RCTs: randomized controlled trials; PR: pulmonary rehabilitation; CG: control group; FVC%: forced vital capacity; DLCO%: diffusion capacity for carbon monoxide; 6MWD: six-minute walk; SGRQ: St. George’s Respiratory Questionnaire; IPAQ: International Physical Activity Questionnaire; IPF-specific SGRQ: St. George’s Respiratory Questionnaire specific for IPF; FEV1: forced expiratory volume in 1 second, test/distance, BDI, baseline dyspnea index; SF-36: social functioning-36.