Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion

Figure 1

High-resolution x-ray imaging and μCT measurement showed that the range and volume of the periapical region expanded gradually with the time on days 0, 7, 14, 21, 28, 35, 42, and 49. (a) Periapical lesion size was revealed by μCT, high-resolution x-ray imaging and hematoxylin-eosin images. The black area around the root apex means comparably low bone intensity (red arrows). The first molar with the periapical lesions was shown in the sagittal, horizontal, and coronal directions (scale bar = 200 μm). (b) Measurements of periapical lesion volume (mm³) in the periapical regions (light blue area). Significant differences were observed at all-time points (P < .05) except on day 42 and 49. (c) Measurements of lesion size (mm²). Significant differences were observed at all-time points (P < .05) except between days 0 and 7 and between days 28 and 35.

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