Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion

Figure 4

The protein expression of CD147 and MMP-9 in CypA inhibitor-treated RAW 264.7 cells. (a) Western bolt analysis showed the different expression of CD147 and MMP-9 under different material treatment. The protein expression of CD147 and MMP-9 were both down-regulated by CsA treatment in RAW 264.7 cells. (b) The ratio of CD147/GADPH and MMP-9/GADPH in different group was showed by bar chart. P < 0.05 versus control group; ^#P < 0.05 versus LPS-treated group; < 0.05 versus CsA-treated group. (c) The role of CypA and CD147 in periapical bone destruction. Released CypA interacts with CD147, which can be found on the surface of inflammatory cells, osteoclasts, and osteoblasts, accelerating inflammatory cytokines production and bone resorption.

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