Integration of Gene Expression Profile Data of Human Epicardial Adipose Tissue from Coronary Artery Disease to Verification of Hub Genes and Pathways

Table 2

The significantly enriched analysis of differentially expressed genes in coronary artery disease.

Expression	Category	Term	Description	Gene count	-value
UP-DEGs	BP	B cell receptor signaling pathway	GO:0050853	6	2.74E-06
	BP	Adaptive immune response	GO:0002250	6	3.55E-04
	BP	GO:inflammatory response	GO:0006954	8	9.15E-04
	BP	Negative regulation of protein phosphorylation	GO:0001933	4	2.02E-03
	BP	Lipopolysaccharide-mediated signaling pathway	GO:0031663	3	7.62E-03
	CC	Plasma membrane	GO:0005886	35	5.28E-06
	CC	Cytosol	GO:0005829	26	7.67E-04
	CC	Extracellular space	GO:0005615	14	2.47E-03
	CC	Anchored component of membrane	GO:0031225	4	1.05E-02
	CC	Extracellular region	GO:0005576	13	2.56E-02
	MF	Identical protein binding	GO:0042802	10	2.44E-03
	MF	Copper ion binding	GO:0005507	3	2.02E-02
	MF	Protein complex binding	GO:0032403	4	4.68E-02
	MF	Integrin binding	GO:0005178	3	6.36E-02
	MF	G-protein alpha-subunit binding	GO:0001965	2	7.18E-02
DOWN-DEGs	BP	Collagen catabolic process	GO:0030574	6	3.55E-05
	BP	GO:cellular response to amino acid stimulus	GO:0071230	5	1.60E-04
	BP	Endodermal cell differentiation	GO:0035987	4	5.09E-04
	BP	Cell proliferation	GO:0008283	9	1.35E-03
	BP	Receptor-mediated endocytosis	GO:0006898	6	4.68E-03
	CC	Extracellular matrix	GO:0031012	10	3.94E-05
	CC	Extracellular exosome	GO:0070062	29	1.09E-03
	CC	Protein complex	GO:0043234	7	2.71E-02
	CC	Cytoplasm	GO:0005737	39	3.18E-02
	CC	Cell-cell adherens junction	GO:0005913	6	3.39E-02
	MF	Rho GDP-dissociation inhibitor binding	GO:0051022	2	2.21E-02
	MF	Ubiquitin protein ligase binding	GO:0031625	6	2.21E-02
	MF	Cadherin binding involved in cell-cell adhesion	GO:0098641	6	2.30E-02
	MF	Protein domain specific binding	GO:0019904	5	2.89E-02
	MF	Lipoprotein lipase activity	GO:0004465	2	4.37E-02