Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters
Table 2
Light microscopy and immunofluorescence findings for patient groups based on GFR and ISKDC classification.
Factors
Renal failure
Chronic renal failure
ISKDC classification
ECr (n=17)
Non-ECr (n=32)
P
CRF (n=13)
Non-CRF (n=36)
P
Class I-II (n=25)
Class III–IV (n=24)
P
Mean±SD or n (%)
Mean±SD or n (%)
Mean±SD or n (%)
Mean±SD or n (%)
Mean±SD or n (%)
Mean±SD or n (%)
Light microscopy studies
Number of glomeruli evaluated
13.8±6.6
19.5±9.6
0.037
13.1±6.7
19.1±9.3
0.046
17.0±8.1
18.1±10.0
0.696
% Glomeruli involved by crescent
13.6±14.6
4.7±8.1
0.036
13.6±13.5
5.7±10.0
0.037
0.0±0.0
15.8±11.8
<0.001
Presence of sclerotic glomeruli [crescent]
10 (62.5)
10 (32.3)
0.047
9 (75.0)
11 (31.4)
0.008
0 (0.0)
20 (87.0)
<0.001
Presence of endocapillary proliferation
2 (11.8)
2 (6.3)
0.602
1 (7.7)
3 (8.3)
0.999
2 (8.0)
2 (8.3)
0.999
Immunofluorescence studies
IgG
0.4±0.7
0.3±0.5
0.564
0.5±0.7
0.3±0.5
0.358
0.4±0.5
0.3±0.6
0.590
IgA
1.8±0.9
1.6±0.8
0.340
1.6±0.9
1.7±0.8
0.614
1.8±0.8
1.5±0.8
0.259
IgM
0.3±0.3
0.2±0.2
0.120
0.3±0.3
0.2±0.2
0.024
0.2±0.2
0.3±0.3
0.245
C3
0.7±0.7
0.5±0.4
0.358
0.7±0.7
0.6±0.5
0.626
0.6±0.4
0.6±0.6
0.671
C4
0.0±0.0
0.0±0.1
0.083
0.0±0.1
0.0±0.1
0.788
0.0±0.1
0.0±0.1
0.585
C1q
0.0±0.0
0.0±0.1
0.161
0.0±0.0
0.0±0.1
0.396
0.0±0.1
0.0±0.0
0.161
Fibrinogen
1.4±1.0
1.1±0.8
0.211
1.3±0.8
1.2±0.8
0.718
1.1±0.8
1.3±0.9
0.424
Chi-square test, Mantel-Haenszel Chi-square test, or Fischer exact test for categorical variables; P-value < 0.05 was considered statistically significant. GFR, glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children.
