Review Article
Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis
Table 2
Summary of relative risks (RRs) for association of age at menopause with risk of the endometrial cancer.
| | Stratification | Number of studies | RR (95% CI) | I2,% | |
| | All studies | 18 | 1.89 (1.58-2.26) | 45.0% | 0.021 | | Continent | | North America | 9 | 1.60 (1.37-1.86) | 0.0% | 0.516 | | Asia | 5 | 3.06 (1.64-5.72) | 63.5% | 0.027 | | Europe | 4 | 2.19 (1.74-2.75) | 0.0% | 0.453 | | Study Design | | Case-control study | 9 | 1.80 (1.36-2.38) | 54.5% | 0.024 | | Cohort study | 9 | 1.98 (1.56-2.52) | 35.4% | 0.135 | | Menopausal type | | Natural menopause | 6 | 1.72 (1.09-2.71) | 67.1% | 0.009 | | Natural menopause and surgical menopause | 5 | 2.25 (1.31-3.85) | 64.0% | 0.025 | | NA | 7 | 1.94 (1.63-2.30) | 0.0% | 0.729 | | Reference group of menopausal age | | ≤45 (<45 or ≤45 or ≤40) | 12 | 2.06 (1.51-2.81) | 60.6% | 0.003 | | ≤50 (<50 or ≤50 or ≤47) | 6 | 1.79 (1.52-2.10) | 0.0% | 0.761 | | The Newcastle-Ottawa score | | 6 or 7 | 5 | 1.59 (1.18-2.15) | 27.1% | 0.241 | | 8 or 9 | 13 | 2.05 (1.64-2.56) | 50.8% | 0.018 |
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RR, relative risk; CI, confidence interval; BMI, body mass index; PMH, postmenopausal hormone
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