Clinical Characteristics and Prognosis of Influenza B Virus-Related Hospitalizations in Northern China during the 2017-18 Influenza Season: A Multicenter Case Series
Table 1
Demographic and clinical characteristics and outcomes of IBV-related hospitalizations (comparison between survivors and nonsurvivors).
All cases (n = 22)
Survivors (n = 16)
Nonsurvivors (n = 6)
value
Age, years
57 (49–70)
57 (50–69)
61 (50–70)
1.000
Male sex (%)
9 (40.9)
6 (37.5)
3 (50)
0.655
Underlying medical conditions
14 (63.6)
9 (56.3)
5 (83.3)
0.351
Smoking history
5 (22.7)
3 (18.8)
2 (33.3)
0.585
Drinking habits
2 (9.1)
2 (12.5)
0 (0)
1.000
Recent surgery history
3 (13.6)
1 (6.3)
2 (33.3)
0.169
Clinical features
Duration before hospitalization (days)
7 (5–10)
7 (5–10)
7 (4–9)
0.858
CURB-65 score ≥2
14 (63.6)
9 (56.3)
5 (83.3)
0.351
Initial PSI score
124 (87–138)
109 (83–133)
140 (123–147)
0.020
PSI class IV or V
16 (72.7)
10 (62.5)
6 (100)
0.133
APACHE II score
15 (12–17)
15 (12–16)
16 (15–19)
0.134
Duration before identification of influenza B virus (days)
11 (7–13)
13 (7–17)
8 (7–10)
0.203
Tmax (°C)
39 (38–39.5)
38.5 (38–39.5)
39 (38.9–39.8)
0.367
Cough
21 (95.5)
15 (93.8)
6 (100)
1.000
Dyspnea
16 (72.7)
11 (68.8)
5 (83.3)
0.634
Myalgia
2 (9.1)
1 (6.3)
1 (16.7)
0.481
Chest pain
6 (27.3)
5 (31.3)
1 (16.7)
0.634
Rhinorrhea
3 (13.6)
3 (18.8)
0 (0)
0.532
Nausea
2 (9.1)
1 (6.3)
1 (16.7)
0.481
Seizure
1 (4.5)
1 (6.3)
0 (0)
1.000
Initial vital signs
Heart rate (beats/min)
103 (96–126)
101 (90–116)
128 (115–135)
0.033
Respiratory rate (breaths/min)
26 (20–30)
25 (20–28)
31 (29–37)
0.115
MAP (mmHg)
94 (82.2–102.9)
96.8 (85.4–103.9)
86.7 (81.2–100.7)
0.494
PaO2/FiO2 ratio (mmHg)
183.3 (119.8–282.9)
183.3 (121.1–285.2)
173.1 (103.6–234.8)
0.541
Hospital-acquired pulmonary infections
15 (68.2)
9 (56.3)
6 (100)
0.121
Management
Antiviral
20 (90.9)
14 (87.5)
6 (100)
1.000
Early antiviral (<48 h)
10 (45.5)
5 (31.3)
5 (83.3)
0.056
Adjuvant IVIG
1 (4.5)
1 (6.3)
0 (0)
1.000
Corticosteroids
5 (22.7)
1 (6.3)
4 (66.7)
0.009
Mechanical ventilation
12 (54.5)
8 (50)
4 (66.7)
0.646
Need for vasopressor
6 (27.3)
4 (25)
2 (33.3)
1.000
ECMO
2 (9.1)
1 (6.3)
1 (16.7)
0.481
Outcomes
Duration of hospitalization (days)
13.0 (12.0–15.0)
13.0 (11.5–15.0)
5.0 (3.0–8.5)
0.010
CURB-65, confusion urea respiratory rate and age 65 scale; PSI, pneumonia severity index; APACHE II, acute physiology and chronic health evaluation II scale; MAP, mean arterial pressure; IVIG, intravenous immunoglobulin; ECMO, extracorporeal membrane oxygenation. Statistically significant.
