Analysis of the Relationship between Adult Asthma and Stroke: A Longitudinal Follow-Up Study Using the Korean National Sample Cohort
Table 4
Subgroup analysis of crude and adjusted hazard ratios (95% confidence interval) of asthma for hemorrhagic and ischemic stroke according to medication histories.
Characteristics
Hemorrhagic stroke
Ischemic stroke
Crude
p-value
Adjusted†
p-value
Crude
p-value
Adjusted†
p-value
Systemic corticosteroid and inhaled corticosteroid use with/without other medication (n = 81,556)
Asthma
1.00 (0.87-1.14)
0.983
1.01 (0.88-1.15)
0.946
1.03 (0.96-1.11)
0.391
1.01 (0.94-1.09)
0.742
Control
1.00
1.00
1.00
1.00
Systemic corticosteroid use without inhaled corticosteroid, with/without other medication (n = 143,778)
Asthma
0.76 (0.66-0.87)
<0.001
0.75 (0.65-0.86)
<0.001
0.81 (0.76-0.88)
<0.001
0.79 (0.73-0.85)
<0.001
Control
1.00
1.00
1.00
1.00
Inhaled corticosteroid use without systemic corticosteroid, with/without other medication (n = 5,658)
Asthma
0.75 (0.34-1.63)
0.468
0.79 (0.36-1.72)
0.555
0.82 (0.55-1.23)
0.344
0.85 (0.56-1.27)
0.424
Control
1.00
1.00
1.00
1.00
Other medications without systemic corticosteroid and inhaled corticosteroid (n = 3,736)
Asthma
0.08 (0.01-0.65)
0.017
0.08 (0.01-0.64)
0.017
1.05 (0.64-1.72)
0.852
1.15 (0.70-1.89)
0.587
Control
1.00
1.00
1.00
1.00
Cox proportional hazards regression model, significance at p < 0.05. † Adjusted model for age, sex, income, region of residence, hypertension, diabetes, hyperlipidemia, ischemic heart disease, and depression histories.
