Scientific Validation of Ethnomedicinal Use of Ipomoea batatas L. Lam. as Aphrodisiac and Gonadoprotective Agent against Bisphenol A Induced Testicular Toxicity in Male Sprague Dawley Rats

Table 7

Cytotoxicity assessment on testes by comet parameters.

Sample	Comet length (μm)	Head; length (μm)	Tail; length (μm)	% DNA; in head	% DNA; in tail	Tail moment (μm)
Control	42.6±3.1	36.7±2.5	5.9±0.3	86.1±2.8	13.9±1.8^β	0.11±0.03^β
Vehicle (10% DMSO)	43.3±2.8	37.2±2.4	6.1±0.4	85.9±1.3	14.1±1.9^β	0.12±0.03^β
Sildenafil (10 mg/kg)	40.4±4.2	35.9±1.8	4.5±0.5	88.8±2.1	11.2±1.3^β	0.11±0.04^β
BPA (50 mg/kg)	44.6±3.6	27.1±2.7	17.5±1.4	60.1±3.5	39.9±1.8^¥	1.27±0.11^¥
IPT- EA (300 mg/kg)	39.5±1.2	34.6±2.5	4.9±0.7	87.5±3.7	12.5±1.4^β	0.12±0.02^β
IPT-M (300 mg/kg)	42.1±3.2	35.7±1.7	7.4±1.1	84.8±2.2	15.2±1.8^β	0.13±0.06^β
IPA-EA (300 mg/kg)	43.7±2.6	38.2±1.3	5.5±0.8	87.5±1.7	12.5±1.2^β	0.11±0.03^β
IPA-M (300 mg/kg)	37.6±1.9	31.5±1.5	6.1±0.6	83.8±3.6	16.2±1.1^β	0.14±0.04^β
BPA+IPT-EA (300 mg/kg)	41.4±2.4	31.7±1.8	9.7±1.3	76.5±1.8	23.5±2.6^β¥	0.24±0.03^β¥
BPA+IPT-EA (150 mg/kg)	43.9±2.8	32.4±2.9	8.5±0.9	80.6±3.1	19.4±2.5^β	0.20±0.06^β¥
BPA+IPT-M (300 mg/kg)	40.1±2.7	32.5±1.4	7.6±1.0	81.1±2.4	18.9±1.3^β	0.16±0.04^β
BPA+IPT-M (150 mg/kg)	42.4±3.3	33.9±2.1	9.4±1.2	79.9±1.5	20.1±2.4^β¥	0.21±0.05^β¥
BPA+IPA-EA (300 mg/kg)	37.1±1.2	31.6±1.1	5.5±0.6	85.1±3.6	14.9±1.1^β	0.14±0.04^β
BPA+IPA-EA (150 mg/kg)	40.3±2.8	33.5±2.9	6.8±0.9	83.1±3.1	16.9±2.5^β	0.18±0.06^β
BPA+IPA-M (300 mg/kg)	42.6±3.1	33.1±2.1	9.5±1.2	77.7±1.5	22.3±2.4^β¥	0.20±0.05^β¥
BPA+IPA-M (150 mg/kg)	41.2±3.3	31.9±2.4	9.3±1.0	77.4±1.5	22.6±1.9^β¥	0.21±0.05^β¥

BPA, bisphenol A, IPA, I. batatas aerial, and IPT, I. batatas tuber extract. Values are expressed as Mean±SD (n=7). Means with symbol “^β” indicate nonsignificant difference from normal control; “^¥”from BPA treated group according to Kruskal-Wallis test at P < 0.05.