Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury

<div>AP-1-subunit-centered regulatory network. (a) Representation of AP-1-subunit-centered regulatory network. Yellow circles: differentially expressed genes (DEGs). Blue circles: ischemia/reperfusion (I/R) injury related genes. Purple circles: genes that are both DEGs and I/R injury related genes. Red diamonds: transcription factors (TFs). (b) Venn diagram representation of overlap of I/R related genes, AP-1 target genes and DEGs. (c) AP-1-mRNA/miRNA and miRNA–mRNA regulatory network. Blue circles: mRNAs. Green circles: miRNAs. Red diamonds: TFs.</div>

BioMed Research International

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Figure 2

Figure 2: Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury 

Figure 2 | Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury 