Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury

Figure 6

Model of AP-1/ AP-1-dependent miRNAs/PTEN regulation mechanism. In the hepatic ischemia/reperfusion, AP-1 is activated, which activates downstream PTEN. At the same time, AP-1-dependent miRNAs are also activated. These miRNAs have targeted PTEN and negatively regulate PTEN. In this way, AP-1 forms a very precise regulation of PTEN during hepatic ischemia/reperfusion.