Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells

Figure 1

Schematic diagram of two-cell–two-gonadotropin theory in ovarian steroidogenesis. Theca cells autonomously produce androstenedione from cholesterol via the positive regulation of steroidogenic enzymes by LH/cAMP/PKA pathway. Granulosa cells convert androstenedione into estradiol. It is promoted by FSH/cAMP/PKA pathway.