Handling Noise in Protein Interaction Networks

Figure 1

Diagram of the OM methodology pipeline. A Reference Set of an organism is used to create a network model, and the respective OM matrix is obtained, using the topological properties. The threshold (OM THR) is calculated using the ROC curve and choosing the value that best separates interaction distributions from noninteraction distributions. The OM THR is then applied to denoise a lower-confidence Data Set network of the same organism, using the respective OM matrix.