Does Supersonic Shear Wave Elastography Help Differentiate Biliary Atresia from Other Causes of Cholestatic Hepatitis in Infants Less than 90 Days Old? Compared with Grey-Scale US
Table 6
Diagnostic performance of hepatic Young’s modulus values, typical grey scale ultrasound findings, and their combination to diagnose BA for all infants with cholestatic hepatitis.
P value
AUC
P value vs SWE
95%CI
Sensitivity
Specificity
PPV
NPV
Accuracy
SWE
<0.001
0.937
0.894,0.978
84.3%
89.7%
82.7%
90.7%
87.7%
TC
<0.001
0.863
>0.05
0.787,0.939
72.5%
100%
100%
86.1%
89.8%
AbGB
<0.001
0.94
>0.05
0.895,0.986
96.1%
92.0%
87.5%
97.6%
93.5%
SWE or TC
<0.001
0.899
>0.05
0.839,0.959
90.2%
89.7%
83.6%
94.0%
89.8%
SWE or AbGB
<0.001
0.908
>0.05
0.857,0.959
100%
81.6%
76.1%
100%
88.4%
TC or AbGB
<0.001
0.96
>0.05
0.926,0.994
100%
92.0%
87.9%
100%
94.9%
SWE or TC or AbGB
<0.001
0.908
>0.05
0.857,0.959
100%
81.6%
76.1%
100%
88.4%
SWE and TC
<0.001
0.833
<0.05
0.751,0.915
66.7%
100%
100%
83.6%
87.7%
SWE and AbGB
<0.001
0.902
>0.05
0.849,0.975
80.4%
100%
100%
90.6%
93.5%
TC and AbGB
<0.001
0.843
<0.05
0.763,0.923
68.6%
100%
100%
84.5%
88.4%
SWE and TC and AbGB
<0.001
0.814
<0.05
0.728,0.899
62.7%
100%
100%
82.1%
86.2%
compared with the AUC of SWE; or: in the parallel test; and, in the serial test; PPV: positive predictive value; NPV: negative predictive value.
