Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma

Figure 3

Paeoniflorin inhibited HGF-mediated cell migration, invasion, and actin cytoskeleton arrangement in T98G and U251. (a-d) Paeoniflorin inhibited HGF-induced cell migration. (e-h) Paeoniflorin inhibited HGF-induced cell invasion. (i, j) Paeoniflorin inhibited HGF-induced cell actin cytoskeleton arrangement. Control: no treatment; PF: 10μM paeoniflorin treatment for 24h. HGF: 20ng/ml HGF treatment for 24h; PF+HGF: 20ng/ml HGF combined with 10μM paeoniflorin incubation for 24h. All tests were performed in triplicate and presented as mean ± standard error. P < 0.05, compared with control group. P < 0.05, compared with HGF group.

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