Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma

Figure 5

SU11274 suppressed HGF-mediated migration, invasion, and actin cytoskeleton arrangement T98G and U251 cells were incubated with 20 ng/ml of HGF for 24 hours and c-Met inhibitors SU11274 (5 μmol/l) was used 4 hours before HGF treatment. (a-d) SU11274 inhibited HGF-induced cell migration. (e-h) SU11274 inhibited HGF-induced cell invasion. (i-j) SU11274 inhibited HGF-induced cell actin cytoskeleton rearrangement. Control: no treatment; HGF: 20ng/ml HGF; SU: c-Met inhibitor SU11274 (5μmol/l); HGF+SU: 20ng/ml HGF combined with 5μmol/l SU11274 (5μmol/l) treatment. All tests were performed in triplicate and presented as mean ± standard error. P < 0.05, compared with control group. P < 0.05, compared with HGF group.

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