Clinical Study
DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo
Figure 1
Epidermal presence of 5-methylcytosine. Representative comparison of indirect immunofluorescences of skin biopsies from melasma patients. The unaffected skin exhibits a decreased fluorescence (a), and melasma skin shows a bright fluorescence in dermis and epidermis (b) (x400).