Pharmacokinetics and Safety of Icotinib Hydrochloride Cream in Patients with Mild to Moderate Chronic Plaque Psoriasis: A Randomized Double-Blind Vehicle-Controlled Phase 1 Study

Table 1

Demographic data of the patients in each group.

		Dose group					Total	P value
		0.5%	1.0%	2.0%	4.0%	Vehicle
N		8	9	8	8	7	40
Age (yr)	Mean ± SD	42.4 ± 7.93	36.6 ± 13.92	40.3 ± 12.8	41.8 ± 12.49	46.0 ± 14.74	41.2 ± 12.31	0.6689
	Median	41.5	31	37.5	43.5	52	41.5
	Range	33-56	22-55	24-58	25-56	21-59	21-59
Gender (M/F)		6/2	5/4	8/0	6/2	6/1	31/9	0.2999
Height (cm)	Mean ± SD	168.1 ± 6.16	164.5 ± 7.39	167.7 ± 5.55	165.0 ± 6.44	170.4 ± 4.84	167.0 ± 6.26	0.3406
	Median	169.5	164.4	168.0	162.5	172.0	167.8
	Range	155-174	155-180	157-174	156-173	164-175	155-180
Weight (kg)	Mean ± SD	67.74 ± 11.53	65.06 ± 10.55	64.06 ± 10.16	66.95 ± 10.51	67.67 ± 8.01	66.23 ± 9.86	0.9338
	Median	66.5	65.7	62.35	67	66.3	66.15
	Range	55-84.1	49-79.3	53.5-79.5	46.4-80	56-78.6	46.4-84.1
BMI (kg/m^2)	Mean ± SD	23.9 ± 3.07	24.04 ± 3.63	22.76 ± 3.34	24.53 ± 3.17	23.39 ± 3.26	23.74 ± 3.19	0.8553
	Median	24.3	22.9	22.8	24.75	21.9	23.95
	Range	19.3-27.8	19.1-28.7	19.0-28.2	19.1-29.7	19.8-27.8	19.0-29.7