Pharmacokinetics and Safety of Icotinib Hydrochloride Cream in Patients with Mild to Moderate Chronic Plaque Psoriasis: A Randomized Double-Blind Vehicle-Controlled Phase 1 Study

Table 2

Main pharmacokinetic parameters after single and multiple doses in each concentration group.

		(ng/ml)			(ngh/ml)			(h)
Group	Administration	Average	Max	Min	Average	Max	Min	Median	Max	Min
0.5%	SD	0.039	0.069	0.006	0.300	0.635	0.012	9.97	12.03	4
	MD	0.340	1.220	0.026	3.168	9.080	0.284	2.01	11.98	0
1.0%	SD	0.050	0.107	0.005	0.349	0.780	0.032	6.03	12.02	2
	MD	0.337	0.680	0.149	2.570	4.927	1.057	2.04	12	0
2.0%	SD	0.051	0.154	0.016	0.340	0.741	0.097	6	12	2
	MD	1.165	2.910	0.146	7.426	20.494	0.922	4	12	0
4.0%	SD	0.099	0.214	0.023	0.735	1.627	0.172	8	12	4
	MD	1.737	3.950	0.426	9.152	13.928	2.828	2	8	0