The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment
Table 1
Types and characteristics of nanodrug delivery systems.
Type
Structure
Drug loading
Advantages
Limitations
Liposomes
Lipid bilayer
Physical entrapment
Great biocompatibility, no immunogenicity
Low stability, hydrophilic drug easily leaks out
Nanoparticles
Nanosphere-/nanocapsule-/polymer-based nanoparticles with a lipophilic core
Physical encapsulation/chemical bonds
High drug-loading capability
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Polymeric micelles
Core-shell structure formed by self-assembly
Physical packing/chemical bonding
Easy to prepare, increased stability of hydrophobic drugs
Low stability, depolymerizes after dilution
Polymer-drug conjugates
Conjugation of drugs with biodegradable polymers
Chemical bond
Increased drug solubility, high drug-loading capability
