Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation
Figure 3
Aortic diameter on ultrasonography, macroscopic findings, aortic diameter, and incidence of aortic aneurysm in the montelukast group (n=7) and the Saline group (n=7). (a) Ultrasonography shows long-axis views of the thoracoabdominal aorta. (b) Aortic aneurysm formation is significantly suppressed in the montelukast group compared with the Saline group. (c) Representative macroscopic images indicate that aortic aneurysms developed in the Saline group but not the montelukast group. (d) At day 28 after implantation, the aortic diameter in the montelukast group is significantly lower than that in the Saline group. (e) The incidence rate of aortic aneurysm is 100% in the Saline group, compared with 14.3% in the montelukast group. Data are presented as the mean ± standard error of the mean. (b) , (d, e) .