Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation

<p>Immunofluorescence staining. (a) In immunofluorescence staining of M1 and M2 macrophages, nitric oxide synthase (iNOS)–labeled M1 macrophages are shown in red, and arginase-1-labeled M2 macrophages are shown in green. Nuclei are stained blue. (b) Quantitative analysis of iNOS-positive and arginase-1-positive cells as ratios relative to the total number of cells (nuclei) shows that the percentage of M1 macrophages is significantly higher in the Saline group than in the montelukast group, and the percentage of M2 macrophages is significantly higher in the montelukast group than in the Saline group. (c) Quantitation of the iNOS-positive cells divided by the arginase-1-positive cells (%). Data are presented as the mean ± standard error of the mean. 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BioMed Research International

fig7

Figure 7

Figure 7: Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation 

Figure 7 | Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation 