Review Article
Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis
Table 1
Characteristics of included RCTs. F/U: follow-up; PRF: platelet-rich fibrin; ALN: alendronate; OFD: open flap debridement; SRP: scaling and root planing; HA: hydroxyapatite; β-TCP: beta-tricalcium phosphate; PPD: pocket probing depth; VCAL: vertical clinical attachment level; HCAL: horizontal clinical attachment level; IBD: Intrabony defect depth.
| | Study ID | Study Type (Study Design) | Patients
(Defect Type) | Control | Intervention | F/U PERIOD (MONTHS) | OUTCOMES |
| | Kanoriya 2016 | RCT, parallel | Intrabony defects | RPF+OFD | RPF+1%ALN+OFD | 9mons | PPD reduction; VCAL-regained;
IBD Depth reduction | | Kanoriya 2017 | RCT, parallel | degree II furcation defects | RPF+OFD | RPF+1%ALN+OFD | 9mons | PPD reduction; HCAL-regained; VCAL-regained;
IBD Depth reduction | | Wanikar 2018 | RCT, split-mouth design | degree II furcation defects | RPF+OFD | RPF+1%ALN+OFD | 6mons | PPD reduction; HCAL-regained; VCAL-regained;
IBD Depth reduction | | Ipshita 2018 | RCT, parallel | degree II furcation defects | placebo gel+SRP | 1%ALN+SRP | 12mons | PPD reduction; HCAL-regained; VCAL-regained;
IBD Depth reduction(%) | | Dutra 2017 | RCT, split-mouth design | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction | | Sharma 2017 | RCT, parallel | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Naineni 2016 | RCT, parallel | Intrabony defects | Saline+β-TCP+OFD | 1%ALN+Saline+β-TCP+OFD | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Pradeep 2017 | RCT, parallel | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 9mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Pradeep 2013 | RCT, parallel | degree II furcation defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 12mons | PPD reduction; HCAL-regained; VCAL-regained;
IBD Depth reduction(%) | | Pradeep 2012 | RCT, parallel | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Sharma 2012 A | RCT, parallel | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Sharma 2012 B | RCT, parallel | Intrabony defects | placebo gel+SRP | 1%ALN+placebo gel+SRP | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction(%) | | Gupta 2011 | RCT, split-mouth design | Intrabony defects | HA+saline+OFD | 1%ALN+saline+HA+OFD | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction | | Veena 2010 | RCT, split-mouth design | Intrabony defects | placebo gel+OFD | 1%ALN+placebo gel+OFD | 6mons | PPD reduction; VCAL-regained;
IBD Depth reduction |
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