Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea
Figure 1
IH induces cardiac perivascular fibrosis and PHD3 overexpression improves it. (a) Representative images of the heart section with Picrosirius Red staining (red, yellow, and green staining) for each group (original magnification ×400 bars=20 μm). And quantification of Picrosirius red staining. (b) Representative images of the heart section with immunohistochemical staining of collagen I and collagen III (yellow staining) for each group (original magnification ×400 bars=20 μm). Quantification of collagen I and collagen III. Data are mean ± SD; n=10 per group. p<0.05 versus control. (c) Representative images of the heart section with Picrosirius red staining (red, yellow, and green staining) and immunohistochemical staining of collagen I and collagen III (yellow staining) for each group (original magnification ×400 bars=20 μm). (d) Quantification of Picrosirius red staining (d1), collagen I (d2), and collagen III (d3). Data are mean ± SD; n=10 per group. p<0.01 versus control; p<0.05 versus IH+LvNC.