Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea
PHD3 overexpression improved IH-induced VSMCs phenotypic switching. (a) Representative images of immunohistochemical staining of OPN (yellow staining) in the perivascular and vascular region (original magnification ×400 bars=20 μm). (b) Quantification of immunohistochemical staining of OPN in vivo. (c) Western blot analysis and quantification of α-SMA (c1 c2) and OPN (c1 c3) in vitro. (d) Western blot analysis and quantification of collagen I (d1 d2) and collagen III (d1). Data are mean ± SD; p<0.05 versus control; p<0.01 versus control; p<0.05 versus IH+LvNC; p<0.01 versus IH+LvNC.
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