Pretreatment with Gemcitabine/5-Fluorouracil Enhances the Cytotoxicity of Trastuzumab to HER2-Negative Human Gallbladder Cancer Cells In Vitro and In Vivo

Table 1

Schedule of treatment with various drugs in each group.

Group	Day 0	Day 3	Day 6	Day 9	Day 12	Day 15	Day 18
Control(n=8)	NS	-	NS	-	NS	-	-
H(n=9)	H	-	H	-	H	-	-
G(n=9)	G	-	G	-	G	-	-
GH(n=9)	G	G	G	H	H	H	-
H+G(n=9)	H+G	-	H+G	-	H+G	-	-
HG(n=9)	H	H	H	G	G	G	-
F(n=8)	F	-	F	-	F	-	-
FH(n=8)	F	F	F	H	H	H	-
H+F(n=8)	H+F	-	H+F	-	H+F	-	-
HF(n=8)	H	H	H	F	F	F	-

The control group was intraperitoneally injected of normal saline. The dosages of various drugs using in treatment groups were as follows: normal saline, NS (20mg/kg, i.p.); GEM, G (100mg/kg, i.p.); 5-Fu, F (30mg/kg, i.p.); and Herceptin, H (20mg/kg, i.p.).