Amides Derived from Vanillic Acid: Coupling Reactions, Antimicrobial Evaluation, and Molecular Docking
Table 1
Minimum inhibitory concentration (MIC), maximum fungicidal concentration (MFC) values, and MFC/MIC in μmol/mL in amides (1-10) against strains of the genus Candida.
Amides
Candida albicans
Candida glabrata
Candida krusei
Candida guilliermondii
(ATCC 90028)
(ATCC 90030)
(ATCC 34125)
(207)
MIC
MFC
MFC/MIC
MIC
MFC
MFC/MIC
MIC
MFC
MFC/MIC
MIC
MFC
MFC/MIC
1
4.48
4.48
1
+
+
+
+
+
+
2.24
2.24
1
2
+
+
+
+
+
+
+
+
+
2.25
2.25
1
3
4.00
4.00
1
+
+
+
+
+
+
2.00
2.00
1
4
2.17
2.17
1
2.17
2.17
1
4.34
4.34
1
2.17
2.17
1
5
3.88
3.88
1
+
+
+
+
+
+
1.94
1.94
1
6
1.81
1.81
1
3.62
3.62
1
3.62
3.62
1
1.81
1.81
1
7
+
+
+
3.68
3.68
1
+
+
+
0.46
0.46
1
8
3.48
3.48
1
+
+
+
+
+
+
+
+
+
9
+
+
+
+
+
+
+
+
+
1.66
1.66
1
10
+
+
+
+
+
+
+
+
+
1.57
1.57
1
Control medium
-
-
-
-
-
-
-
-
-
-
-
-
Nistatin
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
0.00043
Control microorganism
+
+
+
+
+
+
+
+
+
+
+
+
+: microorganism growth. -: no microorganism growth.
