Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice

Figure 10

Proinflammatory responses of angiotensin II in aorta of mice. In the presented scheme, Ang II induces a fast macrophage migration to PVAT, possibly increasing iNOS and IL1-β expression. A secondary macrophage migration to tunica media may be related to a late increase of iNOS and IL1-β expression. On the other hand, TGF-β quickly increases in tunica media. The reason why the late expression of TGF-β in adventitia and PVAT could be influenced by earlier TGF-β expression or by macrophages infiltration needs to be investigated.