Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice

Figure 2

Immunostaining for inflammatory markers in aorta of mice. Positive staining for IL1-β increased in earlier period (30 minutes) in tunica adventitia and perivascular adipose tissue (PVAT) and in a long period (48 hours) in tunica media, tunica adventitia, and PVAT after angiotensin II injection. Angiotensin II increased immunostaining for TGF-β in acute and late periods in tunica media and later in tunica adventitia. iNOS immunostaining increased in adventitia 48 hours after Ang II injection, while in PVAT increased earlier, after 30 minutes. N=7/group. ≤0.05; ≤0.01; ≤0.001 compared to control.