Combined Analysis of the Aberrant Epigenetic Alteration of Pancreatic Ductal Adenocarcinoma

Table 3

Literature search of key hypermethylation genes screened by MethylMix criteria.

Gene symbol	Gene name	Chromosome	Tumor suppressor gene in cancer	Hypermethylated gene in cancer	Altered pathways	Cancer type
CDO1	Cysteine dioxygenase type 1	5q22.3		Hypermethylation	Viral mRNA translation; metabolism	Colorectal cancer; hepatocellular carcinoma; gastric cancer; prostate cancer; esophageal squamous cell carcinoma
GJD2	Gap junction protein delta 2	15q14		Hypermethylation	Gap junction; G-beta gamma signaling	Colorectal cancer
ID4	Inhibitor of DNA binding 4, HLH protein	6p22.3	Tumor suppressor gene	Hypermethylation	TGF-beta signaling pathway (KEGG); signaling pathways regulating pluripotency of stem cells	Breast cancer; acute leukemia
NOL4	Nucleolar protein 4	18q12.1	Tumor suppressor gene			Head and neck cancer; cervical cancer
PAX6	Paired box 6	11p13		Hypermethylation		Gastric cancer; breast cancer
TRIM58	Tripartite motif containing 58	1q44		Hypermethylation		Colorectal cancer; lung squamous cell carcinoma; hepatocellular carcinoma
ZNF382	Zinc finger protein 382	19q13.12	Tumor suppressor gene	Hypermethylation	Generic transcription pathway	Gastric cancer; pediatric acute myeloid leukemia