Melittin Inducing the Apoptosis of Renal Tubule Epithelial Cells through Upregulation of Bax/Bcl-2 Expression and Activation of TNF-α Signaling Pathway

Figure 2

Apoptosis of mice renal tissue observed by TUNEL staining and electron microscope. TUNEL staining showing the apoptosis cells (green) in mice renal tissue (a). Magnification×100. P (compared with the control): <0.05, <0.001. The ultrastructure of renal tubular epithelial cells observed by electron microscopy (b). The arrows show normal nucleus and mitochondria (A), and chromatin margin set, nuclear shrinkage or swollen mitochondria (B, C, D, E).

(a)

(b)