The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn’s Disease instead of Intestinal Tuberculosis in a Chinese Han Population
Table 1
Baseline characteristics of study population.
HC (n=700)
ITB (n=148)
CD (n=145)
P-value
Gender (Female/Male)
332/368
48/100
47/98
0.80
Age of diagnosis (years)
38.5 ± 12.8
41.7 ± 16.7
36.6 ± 15.2
0.008
Smoker, n (%)
144/700(20.6)
35/148 (23.6)
27/145 (18.6)
0.29
Drinker, n (%)
79/700(11.3)
19/148 (12.8)
18/145 (12.4)
0.91
WBC (/L)
7.15 ± 3.9
7.72 ± 3.4
0.30
Hb, g/L
110.20 ± 24.2
108.37 ± 25.5
0.56
ESR, mm/h
38.15 ± 24.8
35.20 ± 23.9
0.47
PPD (positive), n (%)
38/56 (67.9)
15/43 (34.9)
0.07
T-SPOT (positive), n (%)
25/33 (75.8)
3/31 (9.68)
0.0006
Not examined TB
59
71
Abnormal lung imaging findings, n (%)
56/148 (37.8)
4/145 (2.8)
< 0.0001
Remission rate: n (%)
5-ASA
88/145 (60.7)
Glucocorticoid
34/145 (23.4)
Immunosuppressor
7/145 (4.8)
Anti-TNF
9/145 (6.2)
Nonremission
7/145 (4.8)
Disease related surgery, n (%)
23/148 (15.5)
33/145 (22.8)
0.20
Location of ITB, n (%)
Small Intestine
12/148 (8.1)
Ileocecus
89/148 (60.1)
Colon
39/148 (26.4)
Data not available
8/148 (6.0)
Location of CD, n (%)
L1± L4
67/145 (46.2)
L2± L4
41/145 (28.3)
L3± L4
34/145 (23.4)
L4
3/145 (2.0)
Behavior of CD, n (%)
B1—Inflammatory
95/145 (65.5)
B2—Stricturing
45/145 (31.0)
B3—Penetrating
10/145 (6.9)
p—Perianal
37/145 (25.5)
Smoker: subjects who had smoked more than one cigarette per day for at least one year; drinker: subjects who drank alcohol per week for more than six months; ESR: erythrocyte sedimentation rate; PPD, tuberculin skin testing. Crohn's disease phenotype defined by the Montreal Classification System, L1, Terminal ileum; L2, colonic; L3, ileocolonic; L4, upper GI. P-value means comparison between ITB and CD groups. Bold italics indicate the statistical significance (P < 0.05).
