Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis

Table 1

Characteristics of enrolled studies.

Studies	Animals	Group		ZOL dosage and route, or concentration	Implant			FU time
		Number	Size		Site	Type	Coating
Ayan et al. [8]	Male rabbits	1: control	9	0.1 mg/kg IV	Tibia	Titanium screw	No	4 weeks
		2: ZOL		Single dose
Cardemil et al. [9]	Female rats	1: control (OVX)	28	0.1 mg/kg IV	Tibia	Titanium screw	No	4 weeks
		2: ZOL		Single dose
Carvas et al. [10]	Male rabbits	1: control (GC)	6	0.1 mg/kg IV	Tibia	Titanium screw	No	18 weeks
		2: ZOL		Single dose
Chen et al. [11]	Female rats	1: control (OVX)	12	0.1 mg/kg IV	Tibia	Titanium rod	HA	12 weeks
		2: ALN		Single dose
		3: SR
		4: ZOL
Dikicier et al. [12]	Female rats	1: control (OVX)	12	0.04 mg/kg IV	Tibia	Titanium screw	No	8 weeks
		2: ZOL		6 doses
Li et al. [13]	Female rabbits	1: control (OVX)	6	0.1 mg/kg SC	Tibia	Titanium screw	HA	8 weeks
		2: ZOL		3 doses
de Oliveira et al. [14]	Male rats	1: control	3	0.0075 mg/kg SC	Tibia	Titanium	No	4 weeks
		2: ZOL		3 doses
Qi et al. [15]	Female rabbits	1: control (OVX)	8	0.1 mg/kg SC	Tibia	Titanium screw	HA	12 weeks
		2: local ZOL		4 doses
		3: systemic ZOL
		4: local and systemic ZOL
Yaman et al. [16]	Male rats	1: control	7	0.1 mg/kg IV	Tibia	Titanium screw	HA	12 weeks
		2: ZOL		3 doses
Yildiz et al. [17]	Female rabbits	1: control (OVX)	12	0.1 mg/kg IV	Tibia	Titanium screw	Resorbable blast media	8 weeks
		2: ZOL		Single dose
Blazsek et al. [18]	Female rats	1: control	5	0.6 mg/kg IP	Tail vertebra	Titanium screw	No	6 weeks
		2: ZOL		3 doses
von Knoch et al. [19]	Rabbits	1: control	12	0.015 mg/kg IV	Femur	Titanium cylinder	Fiber metal mesh	12 weeks
		2: ZOL		Single dose
Arnoldi et al. [20]	Rabbits	1: control	6	1 μg/ml	Femur	Titanium screw	No	10 days
		2: ZOL
Miettinen et al. [21]	Male rats	1: control	7	20 μg/ml	Femur	Titanium	No	4 weeks
		2: ZOL
Gao et al. [22]	Female rats	1: control (OVX)	10	1 mg/ml	Tibia	Titanium	HA	12 weeks
		2: ZOL
Stadlinger et al. [23]	Female rats	1: control (OVX)	8	8.5 μg/implant	Tibia	Titanium	No	4 weeks
		2: ZOL
Ying et al. [24]	Female rats	1: control (OVX)	10	30 μg/implant	Tibia	Titanium cylinder	No	12 weeks
		2: ZOL
Pyo et al. [25]	Female rats	1: control (OVX)	10	8 μg/ml	Tibia	Titanium screw	No	8 weeks
		2: ZOL		80 μg/ml
				800 μg/ml
Sörensen et al. [26]	Rats	1: control	10	50 μg/implant	Tibia	Calcium phosphate bone cement	No	3 weeks
		2: ZOL
Bobyn et al. [27]	Dogs	1: control	5	0.2 mg/ml	Femur	Tantalum	HA	1 year
		2: ZOL

ZOL: zoledronate; FU: follow-up; GC: glucocorticoid; HA: hydroxyapatite; ALN: alendronate; SR: strontium ranelate; SC: subcutaneous; IP: intraperitoneal.