Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota

Figure 4

Treatment with XQLT prevents fibrosis in rats with heart failure with preserved ejection fraction (HFpEF). (a) Masson staining of the left ventricle is shown; the % area of fibrosis was assessed by analysis of the Masson staining. (b) The fibrosis-associated protein expression of collagen I and collagen III in the left ventricle was assessed using western blot analysis and was compared with that in the NS group. The data are presented as the mean±SD (n=6 rats per group). p < 0.05 and p < 0.01 compared with the NS group; p <0.05 and p <0.01 compared with the HS group.

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