Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota

Figure 9

Effects of fecal transplantation from XQLT-treated rats on echocardiography measurements, organ weights, and blood test results. Seven-week-old specific pathogen-free male Dahl salt-sensitive rats were fed 8% NaCl chow for 11 weeks and colonized with fecal samples from different groups for 4 weeks. Then, the (a) wall thickness (WT) (b) left ventricular mass (LV mass), (c) left ventricular diastolic diameter (LVDd), (d) left ventricular ejection fraction (LVEF), (e) heart weight/body weight ratios, (f) lung weight/body weight ratios, and (g) NT-proBNP levels were measured. The data are presented as the mean± SD (n=5 rats per group). p < 0.05 and p < 0.01 compared with the FMT NS group; p <0.05 and p <0.01 compared with the FMT HS group.

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