The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma

Table 3

Sex, smoking history, and GGO volume percentage according to EGFR mutation subtype.

Subtype	N	Sex			Smoking history			GGO
		Women	Men	p-value	Never-smoker	Smoker	p-value	volume percentage (%) (range)	p-value
Exon 19 deletion	76	39	37	p = 0.040^∥	43	33	p = 0.009^∥	40.8 ± 28.9%	0.064
Exon 21 missense	74	44	30	p = 0.002^∥	47	27	P < 0.001^∥	65.2 ± 19.3%	P < 0.001
Exon 20 insertion	8	4	4	p = 0.461^‡	4	4	p = 0.331^‡	38.1 ± 9.4%	0.039^§
Exon 18 insertion	5	3	2	p = 0.298^‡	3	2	p = 0.512^‡	47.3 ± 5.7%	0.083^§
EGFR-	146	54	92		56	90		29.0 ± 20.7%
Total	309	180	129		163	146

Note: p-value based on a comparison between adenocarcinomas with each EGFR mutation subtype and adenocarcinomas without EGFR mutation.
Significant differences were found in GGO volume percentage between adenocarcinomas with exon 19 deletion and adenocarcinomas with exon 21 missense mutations (p<0.001) using independent t-tests.
independent t-tests.
∥ χ2 tests
‡ Fisher’s exact test
§ Mann-Whitney U -test