Identification of commonly changed DEGs from the three cohort profile datasets (GSE33630, GSE29265, and GSE65144) and the hierarchical clustering analysis of DEGs. (a-b) Venn diagram displayed consistently up- and downregulated DEGs in three groups. (câ€“e) Top 20 up- and downregulated DEGs depending on fold changes were hierarchically clustered and displayed by heatmap. Probe values (log2 transformation) of each gene were normalized by row Z-score, respectively. DEGs, differentially expressed genes.