Uncoupling Protein 2 Drives Myocardial Dysfunction in Murine Models of Septic Shock

Figure 3

Knockdown of UCP2 preserved mitochondrial function in cardiomyocytes. (a) The intracellular ATP levels in the hearts 12 h after intraperitoneal injection of PBS or LPS in AAV9-NC or AAV9-shUCP2 mice. (b) Mitochondrial membrane potential, indicated by TMRE fluorescence of adult mice cardiomyocytes freshly isolated 12 h after intraperitoneal injection of PBS or LPS in AAV9-NC or AAV9-shUCP2 mice. P < 0.05, P < 0.01, and P < 0.001 vs. the corresponding group. All data represent the mean ± SEM from at least 3 independent experiments.

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