Uncoupling Protein 2 Drives Myocardial Dysfunction in Murine Models of Septic Shock

Figure 5

3-Methyladenine abolished the protective role of UCP2 knockdown in LPS-challenged mice. (a-b) WT and UCP2 knockdown mice were insulted with LPS i.p. 3-methyladenine was administered i.p. 30 minutes after LPS challenge. Cardiac function was measured 18 hours after LPS challenge. Representative images and results of echocardiographic assessment (n = 5 for each group). Data were presented as means ± SEM. P < 0.05, P < 0.01, and P < 0.01 vs. the indicated group. (c) Survival was monitored in LPS (10 mg/kg) challenged UCP2 knockdown with or without 3-MA mice. P < 0.001 vs. the AAV-shUCP2+Control group.

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