Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis/Bladder Pain Syndrome

Table 4

Effect of mPEA-POL on frequency (daily + nocturia) and bladder capacity evaluated with 3-day voiding diary.

	Time (months)
	0	2	4	6
Frequency	12.2 ± 1.2	10.7 ± 1.1	11.6 ± 1.1	10.1 ± 1.1	0.0005
Bladder capacity	180.2 ± 19.2	193.7 ± 20.5	196.8 ± 22.9	208.5 ± 22.5	0.0005

Data are expressed as means ± SE; n for frequency = 22, 23, 21, and 19, respectively, at baseline and 2, 4, and 6 months; n for bladder capacity = 21, 22, 21, and 19 at baseline and 2, 4, and 6 months, respectively. refers to changes over time.