Simultaneous Determination of Six <i>Uncaria</i> Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

<div>UPLC-MS/MS chromatograms of rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine, hirsutine, hirsuteine, and IS in mouse blood. (a) Blank blood; (b) blank blood spiked with rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine, hirsutine, hirsuteine, and IS; (c) and a mouse blood after intravenous administration.</div>

BioMed Research International

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Figure 3

Figure 3: Simultaneous Determination of Six <i>Uncaria</i> Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability 

Figure 3 | Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability 