Research Article

Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

Table 5

Pharmacokinetic parameters of rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine, hirsutine, and hirsuteine after oral (po) and intravenous (iv) administration in mice (, ).

ParametersUnitRhynchophyllineIsorhynchophyllineCorynoxeineIsocorynoxeineHirsutineHirsuteine
ivpoivpoivpoivpoivpoivpo

ng/mLh
AUC(0-∞)ng/mLh
h
MRT(0-∞)h
h
VzL/kg
L/h/kg
ng/mL
Bioavailability49.4%29.5%27.3%32.7%68.9%51.0%