TMT-Based Quantitative Proteomic Analysis Identification of Integrin Alpha 3 and Integrin Alpha 5 as Novel Biomarkers in Pathogenesis of Acute Aortic Dissection

Table 2

Downregulated DAPs in AAD patients ().

Accession	Expression of healthy donor	Mean expression of AAD patients ()	log2FC	Description
H3BQZ7	2286.5	69.33333333	-5.04344799	HCG2044799
Q6GMX6	24204.11	1024.248	-4.56261507	IGH@ protein
Q6MZQ6	21830.2	939.36	-4.53850338	Putative uncharacterized protein DKFZp686G11190
Q6N089	19877.09	909.564	-4.4497876	Putative uncharacterized protein DKFZp686P15220
V9HW68	19889.09	1004.376	-4.3076059	Epididymis luminal protein 214
Q92626	2750	187.25	-3.87639399	Peroxidasin homolog
A0A024R971	5098	368.058	-3.79192634	Fibromodulin, isoform CRA_a
A0A087X2C0	5633	410.31	-3.77911725	Ig mu chain C region
A0A024R9G4	1679	122.6666667	-3.77478706	Family with sequence similarity 49, member B, isoform CRA_a
A0A0G2JPD4	6460.29	505.912	-3.67464056	Uncharacterized protein
B0YJ88	4307	350.696	-3.61839044	Radixin
Q96C32	9160.43	752.5633333	-3.60553042	Polyubiquitin-C
A8K3Q7	19376	1632.302	-3.56929086	Annexin
P43652	2496.5	211.875	-3.55862163	Afamin
A0A024R0S6	5116.29	460.624	-3.47343655	EH-domain containing 2, isoform CRA_a
Q9NZU5	5750	529.346	-3.44127902	LIM and cysteine-rich domains protein 1
F2ZC06	3779.75	349.452	-3.43512461	Thyroid hormone receptor interacting protein 6 isoform 1
P26006	4296	414.25	-3.37442039	Integrin alpha 3/beta 1
A8MX94	5754.4	581.104	-3.30779722	Glutathione S-transferase P
B2R6V9	1398	142	-3.29940153	cDNA, FLJ93141, highly similar to Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA
P01023	3824.29	397.764	-3.26520731	Alpha 2-macroglobulin
O94832	1636	170.944	-3.25857706	Unconventional myosin-Id
B4DKT9	4013	422.1666667	-3.24879658	cDNA FLJ54052, highly similar to alpha 1 catenin (cadherin-associated protein)
D6RA82	5307.67	564.375	-3.23335269	Annexin
B4DQG5	2126.25	227.9175	-3.22172763	cDNA FLJ54122, highly similar to Cytosol aminopeptidase (EC 3.4.11.1)
P12235	1117	125.3333333	-3.15578712	ADP/ATP translocase 1
A0A024QZV0	1431	160.625	-3.15525531	HCG1811539, isoform CRA_b
Q6UVK1	1875	210.564	-3.15455989	Chondroitin sulfate proteoglycan 4
A0A0B4J1R6	1682.75	191.546	-3.13505805	Transketolase
B4DRV4	2956	340.5	-3.11791957	cDNA FLJ55667, highly similar to secreted protein acidic and rich in cysteine
A0A024RC65	4177	531.732	-2.97369595	HCG1991735, isoform CRA_a
A0A024RDE1	1252	161.95	-2.95061419	SPARC-like 1 (Mast9, hevin), isoform CRA_a
Q8TCD0	14216	1858.354	-2.93541833	Uncharacterized protein
A0A024RAC9	253	34	-2.89553073	Zinc finger, UBR1 type 1, isoform CRA_c
O76024	2314	313	-2.8861543	Wolframin
B4DQX8	3990	547.875	-2.86447007	cDNA FLJ51723, highly similar to DCC-interacting protein 13 alpha (fragment)
V9HWK1	2754	387.9425	-2.82761382	Triosephosphate isomerase
P49327	1231.5	174.842	-2.81629294	Fatty acid synthase
B4DNM8	360	51.75	-2.79836614	cDNA FLJ53395, highly similar to Prolyl 3-hydroxylase 1 (EC 1.14.11.7)
A0A087WZW8	14216	2052.316	-2.7921908	Protein IGKV3-11
A0A087WUS7	2422	354.7	-2.77152763	Ig delta chain C region
B4E3A8	1457	216.3333333	-2.75167299	cDNA FLJ53963, highly similar to leukocyte elastase inhibitor
A8K3B6	406	60.5	-2.74647268	Nonspecific protein-tyrosine kinase
S6C4R6	12602.88	1884.586	-2.74143392	IgG L chain
A0A087WYL9	14216	2132.92	-2.73661383	Ig kappa chain C region
Q6GMX0	11199.11	1698.368	-2.72116309	Uncharacterized protein
Q6PJF2	9283.64	1452.93	-2.67572538	IGK@ protein
P27824	1292.5	204.5	-2.65999153	Calnexin
Q6P5S8	14216	2252.75	-2.65775646	IGK@ protein
A0A087X130	12702.62	2022.842	-2.65067055	Ig kappa chain C region
A0A087WWT3	646	104	-2.63495064	Serum albumin
V9HW34	9283.64	1502.036	-2.62777119	Epididymis luminal protein 213
Q8NCL6	2879.25	479.72	-2.58542857	cDNA FLJ90170 fis, clone MAMMA1000370, highly similar to Ig alpha 1 chain C region
Q9NPP6	3076.09	515.486	-2.57709256	Immunoglobulin heavy chain variant (fragment)
Q96K68	2872.08	483.564	-2.57031719	cDNA FLJ14473 fis, clone MAMMA1001080, highly similar to Homo sapiens SNC73 protein (SNC73) mRNA
B4DEA3	218	37	-2.55873096	cDNA FLJ56531, highly similar to UV excision repair protein RAD23 homolog B
Q96CD0	228.5	41	-2.47849835	F-box/LRR-repeat protein 8
V9HWF2	1684.5	306.8175	-2.45686775	Malate dehydrogenase
A8K4C8	5080	925.6666667	-2.45626382	60S ribosomal protein L13
A0A024RDY2	860	158.994	-2.43536434	Tumor protein, translationally controlled 1, isoform CRA_a
Q6MZV6	2675.38	500.17	-2.41925339	Putative uncharacterized protein DKFZp686L19235
A0A024RB01	2564	484.4	-2.40412549	Integrin, alpha 5 (fibronectin receptor, alpha polypeptide), isoform CRA_b
A6NLN1	652	123.9175	-2.39549202	Polypyrimidine tract binding protein 1, isoform CRA_b
P07204	989	190.33	-2.37746754	Thrombomodulin
F6U211	253	49.46666667	-2.35460879	40S ribosomal protein S10
P63267	1432	283.6666667	-2.33576296	Actin, gamma-enteric smooth muscle
A0A0C4DFX3	829	164.6666667	-2.33182356	EMILIN-1
A6NNI4	571	114.3333333	-2.32024467	Tetraspanin
A0A024RA21	843	170.8	-2.30322466	Secernin 1, isoform CRA_a
B2R5H0	1174	245.915	-2.25520077	Protein S100
B4DPU3	7412	1556.5	-2.2515573	cDNA FLJ56548, highly similar to elongation factor 2
Q6MZU6	6876.26	1445.532	-2.25002355	Putative uncharacterized protein DKFZp686C15213
A0A024R1N1	1066	224.5	-2.24742009	Myosin, heavy polypeptide 9, nonmuscle, isoform CRA_a
A0A075B6N8	6872.24	1450.324	-2.24440519	Ig gamma-3 chain C region (fragment)
B7Z539	898	192.05	-2.22523348	cDNA FLJ56954, highly similar to interalpha trypsin inhibitor heavy chain H1
A0A024R930	232	49.75	-2.22135637	Proteoglycan 4, isoform CRA_a
A8K9M5	1651.17	354.448	-2.21984277	cDNA FLJ77947, highly similar to human complement protein C8 beta subunit mRNA
A0A024R7Z5	412.5	89.2075	-2.20915721	Syndecan binding protein (Syntenin), isoform CRA_c
B4DDS8	846	184.5	-2.19703685	cDNA FLJ56686, moderately similar to FADD protein
A0A024R3W7	239	52.5	-2.18662129	Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a
A0A087WUN8	371	82	-2.17772337	Syntaxin-binding protein 2
B4DTX5	1412	314.816	-2.16515932	cDNA FLJ60072, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript variant 6, mRNA
Q9BVK6	267	59.75	-2.15982912	Transmembrane emp24 domain-containing protein 9
Q9Y217	430	96.33333333	-2.15822967	Myotubularin-related protein 6
Q8IWB1	194	43.5	-2.15696935	Inositol 1,4,5-trisphosphate receptor-interacting protein
A0A075B6G3	818.5	183.5766667	-2.15659972	Dystrophin
K7EQQ3	6367	1439.5	-2.14504598	Keratin, type I cytoskeletal 9
B4E2F9	1999.32	455.736	-2.13323916	cDNA FLJ57038, highly similar to Filamin-A
C9JAK5	1520	346.7	-2.13231158	ADP-ribosylation factor 4
B7Z9B7	1412	322.75	-2.12925109	cDNA FLJ54732, moderately similar to sorbin and SH3 domain-containing protein 1
B2ZZ89	884	202.512	-2.12603897	Epididymis luminal protein 102
A0M8W4	902	207.5	-2.1200161	Ubiquitin-conjugating enzyme E2 variant 2
B0QZ18	3015	723.296	-2.05949992	Copine-1
A0A024RAX0	676	162.25	-2.05880477	Matrix Gla protein
B0QY01	225	54.125	-2.05555798	Target of Myb protein 1 (fragment)
A0A087WU08	2574	619.875	-2.05396283	Haptoglobin
A0A024R6P0	2748	666.416	-2.04388706	Serpin peptidase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3, isoform CRA_c
A0A024RD41	3012	731.6666667	-2.04146333	RAB23, member RAS oncogene family, isoform CRA_a
A0A024R1Z6	242.5	59	-2.03919789	Vesicle amine transport protein 1 homolog (T. californica), isoform CRA_a
Q59EQ1	478	119.5	-2	Cadherin 11, type 2 isoform 1 preproprotein variant (fragment)

Note: based on protein abundance. A protein was defined as DAPs if there was a log2FC in less of -2.